Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking.
نویسندگان
چکیده
2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
منابع مشابه
Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinkingw
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 10 شماره
صفحات -
تاریخ انتشار 2011